Lidocaine Hydrochloride CAS 73-78-9 Professional Supplier

General:
Lidocaine hydrochloride was synthesized by Löfgren and Lundquist in 1943, and was clinically introduced in 1948. It remains one of the most widely used local anaesthetics. It can be administered parenterally for a peripheral nerve block (PNB), intravenously, or applied topically at strengths of 2–4%. The addition of epinephrine 1:200 000 to 1:100 000 slows the vascular absorption of lidocaine and prolongs its effects.

Physical and chemical properties:
Lidocaine hydrochloride is white and odorless crystal with bitter and numb taste. It is easily soluble in water, ethanol and organic solvents, but insoluble in ether. Aqueous solution in the case of acid and alkali do not break down, repeated autoclave rarely go bad.

Application:
Lidocaine hydrochloride is characterized by strong penetration, strong dispersion, rapidly onset. The anesthetic performance is twice that of procaine and the toxicity is1. There is an anesthetic effect after 5 minutes treatments, and anesthesia can last 1 to 1.5 hours, 50% longer than procaine. The drug is effective on the heart of the disease or arrhythmia caused by cardiac glycoside, but on the supraventricular tachycardia is poor. This product is fast and oral ineffective, with short duration, and often used as intravenous administration.

Metabolism:
Lidocaine is metabolized by the liver with only a small amount (3%) found unchanged in urine. The three main mechanisms of metabolism are shown below: N-de-ethylation > monoethylglycinexylidide (MEGX) > glycinexylidide Hydrolysis of glycinexylidide 5-hydroxylation of lidocaine’s benzene ring Lidocaine possesses convulsant activity. Hepatic disease or reduced hepatic blood flow (as in congestive cardiac failure) will lower metabolic capacity.

Enterprise Certification:

Lihe Pharmaceutical Technology (Wuhan) Co., Ltd. is a pharmaceutical company integrating product development, production and chemical intermediates, specializing in the research, development, production and export of organic intermediates, pharmaceutical intermediates, chemical solvents and pesticides.Loacted in Hubei Province, involving pesticide, medicine, chemical industry, coating, dye, reagent, polyester, petrochemical and other fields. AOP provide excellent products and products for customers according to quality, quantity and time Service, established a good brand reputation and business reputation in the industry, won the trust and support of many customers at home and abroad.since its establishment, the company has always adhered to the principle of people-oriented, technology for survival, quality for credit, service tenet, consistent quality and reputation guarantee, continuous pioneering spirit of business is the cornerstone of our development, and the support and praise of..