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CAS 516-55-2 3b-Hydroxy-5A-Pregnan-20-One / 5alpha-Pregnane-3beta-Ol-20-One / Allopregnan-3beta-Ol-20-One
|ALLOPREGNANOLONE Basic information|
|ALLOPREGNANOLONE Chemical Properties|
|alpha||D27 +91.2° (c = 0.4 in ethanol)|
|Boiling point||431.2±18.0 °C(Predicted)|
|solubility||Chloroform (Slightly), Methanol (Slightly)|
|color||White to Off-White|
Regulation of synthesis and release
Allopregnanolone synthesis is stimulated by swim stress.In swim stress models, increased allopregnanolone is associated with decreased dopamine and norepinephrine in the prefrontal cortex, suggesting that allopregnanolone influences the mesolimbocortical dopamine pathway.In vivo treatment of the rat with the dopamine D4 antagonist clozapine induces a rapid increase in the concentration of allopregnanolone in the cerebral cortex and striatum.
The presence of a progestational compound in the rabbit adrenal gland was reported in 1933, and was isolated in 1938 from the ox adrenal gland.Allopregnanolone formation was demonstrated in the brains of various vertebrates2–5 and the pineal glands of birds.
Allopregnanolone mediates its effects through modulation of the GABAA receptor.Allopregnanolone is reported to modulate the GABA-ergic function by increasing the GABAA receptor opening frequency and duration of the receptor at concentrations in the nanomolar range. A balance between unbinding, desensitization, and reopening of the desensitized GABAA receptor underlies the delay of the inhibitory postsynaptic currents. Allopregnanolone slows the rate of recovery of the GABAA receptor from desensitization and possibly increases the rate of entry into fast desensitized states. Allopregnanolone exerts neurogenetic, neuroprotective, antidepressant, and anxiolytic effects. Reduced levels of allopregnanolone are found to be associated with major depression, anxiety disorders, premenstrual dysphoric disorder, and Alzheimer’s disease. Allopregnanolone is actively produced in the pineal gland compared with the brain and pineal allopregnanolone acts on Purkinje cells to prevent apoptosis in the juvenile quail.
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4. We double clear package tax, accept sample orders, can also provide sample test welcome to consult, we will give you a super cheap price.
Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity more than
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q8: can you give me a discount?
A: Of course, it depends on your quantity
Q9: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q10: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q11: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.
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