Payment & Shipping Terms:
|Melting Point:||121-123 °C (lit.)||Boiling Point:||325.75°C (rough Estimate)|
|Density:||1.0815 (rough Estimate)||Package:||15KG/Drum|
Raw Materials 608-07-1
|5-Methoxytryptamine Basic information|
|Synonyms:||1H-Indole-3-ethanamine, 5-methoxy-;3-(2-aminoethyl)-5-methoxy-indol;5-methoxy-1h-indole-3-ethanamin;5MOT;Ethanamine,2-(5-methoxy-3-indolyl)-;Indole, 3-(2-aminoethyl)-5-methoxy-;Meksamin (free base);Methoxytryptamine|
|Product Categories:||Agonists;Amines;Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Neurochemicals;Indole/indoline/oxindole;Indole and Indoline;Pharmaceuticals;Bioactive Small Molecules;Building Blocks;C11;Cell Biology;Chemical Synthesis;PHARMACEUTICAL INTERMEDIATES;Tryptamines;pharmacetical;Indoline & Oxindole;Indoles;Building Blocks;Heterocyclic Building Blocks;Non-Chiral heterocyclic compounds;Heterocyclic Building Blocks;M;608-07-1|
|5-Methoxytryptamine Chemical Properties|
|Melting point||121-123 °C (lit.)|
|Boiling point||325.75°C (rough estimate)|
|density||1.0815 (rough estimate)|
|refractive index||1.5700 (estimate)|
|solubility||Chloroform (Slightly), Methanol (Slightly)|
|PMK ethyl glycidate||28578-16-7||99%|
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.
5-Methoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.
Reactant for preparation of:
Carboline disaccharide domain of shishijimicin A
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5-HT4 receptor ligands
inhibitors of sortase A and isocitrate lyase
Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
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Manzamine analogues for the control of neuroinflammation and cerebral infections
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Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease
Clinical claims and research
The effects of the 5-HT receptor agonist, 5-methoxytryptamine, on plasma glucose levels were investigated in rats. 5-Methoxytryptamine induced a significant hyperglycemia above the dosage of 1 mg/kg. 5-Methoxytryptamine-induced hyperglycemia was antagonized by pretreatment with the 5-HT1 and 5-HT2 receptor antagonist, methysergide, or the 5-HT2A receptor antagonist, ketanserin, whereas the 5-HT3 and 5-HT4 receptor antagonist, tropisetron, and the 5-HT4 receptor antagonist, SDZ 205-557 (2-methoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester), showed no effect. In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, reduced 5-methoxytryptamine-induced hyperglycemia.
Hyperglycemia induced by the 5-HT receptor agonist, 5-methoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.
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