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| CAS: | 608-07-1 | Product Name: | 5-Me Thoxytryptamine |
|---|---|---|---|
| Melting Point: | 121-123 °C (lit.) | Boiling Point: | 325.75°C (rough Estimate) |
| Density: | 1.0815 (rough Estimate) | Package: | 15KG/Drum |
| High Light: | 99% 5-Methoxytryptaminecas,Raw Materials 608-07-1 |
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Product Specification:
| 5-Me thoxytryptamine Basic information |
| CAS: | 608-07-1 |
| MF: | C11H14N2O |
| MW: | 190.24 |
| EINECS: | 210-153-7 |
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| 5-Me thoxytryptamine Chemical Properties |
| Melting point | 121-123 °C (lit.) |
| Boiling point | 325.75°C (rough estimate) |
| density | 1.0815 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 16.91±0.30(Predicted) |
| form | crystalline |
| color | white |
| Merck | 13,6032 |
| BRN | 145587 |
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Description
5-Me thoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.
The protective effect of 5-me thoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
Uses
5-Me thoxytryptamine (Mexamine, Me thoxytryptamine) is a tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.
Application
5-Me thoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.
Reactant for preparation of:
Carboline disaccharide domain of shishijimicin A
Melatonin analogs for the reduction of intraocular pressure
5-HT4 receptor ligands
inhibitors of sortase A and isocitrate lyase
Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
Aurora and epidermal growth factor receptor kinase inhibitors
Agents for the treatment of human papillomavirus infection
Manzamine analogues for the control of neuroinflammation and cerebral infections
Inhibitors of pro-inflammatory cytokines
Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease
Clinical claims and research
The effects of the 5-HT receptor agonist, 5-me thoxytryptamine, on plasma glucose levels were investigated in rats. 5-Me thoxytryptamine induced a significant hyperglycemia above the dosage of 1 mg/kg. 5-Me thoxytryptamine-induced hyperglycemia was antagonized by pretreatment with the 5-HT1 and 5-HT2 receptor antagonist, methysergide, or the 5-HT2A receptor antagonist, ketanserin, whereas the 5-HT3 and 5-HT4 receptor antagonist, tropisetron, and the 5-HT4 receptor antagonist, SDZ 205-557 (2-me thoxy-4-amino-5-chloro-benzoic acid 2-(diethylamino) ethyl ester), showed no effect. In addition, the peripheral 5-HT2 receptor antagonist, xylamidine, reduced 5-me thoxytryptamine-induced hyperglycemia.
Hyperglycemia induced by the 5-HT receptor agonist, 5-me thoxytryptamine, in rats: involvement of the peripheral 5-HT2A receptor.
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