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Product Name: | Levamisole | CAS No.: | 14769-73-4 |
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Purity: | 99% | Application: | Intermediates |
MF: | C11H12N2S | MW: | 204.29 |
EINECS: | 238-836-5 | Appearance: | White Powder |
High Light: | Cas 14769-73-4 Levamisole,Levamisole White Granular Powder |
Cas 14769-73-4 Levamisole white granular powder high purity
Product Name | Levamisole |
Grade | Pharmaceutical Grade |
CAS NO | 14769-73-4 |
Molecular Formula | C11H12N2S |
Molecular Weight | 204.29 |
Melting point | 60-61.5° |
EINECS NO | 238-836-5 |
Boiling Point | 344.4±45.0 °C(Predicted) |
Flash Point | 162.1±28.7 °C |
Density | 1.32±0.1 g/cm3(Predicted) |
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Pharmacology and mechanism of action:
Levamisole is the L-isomer of tetramisole and is more active than the racemic mixture. It was introduced in 1966 as a veterinary drug and a little later as a human anthelminthic drug against ascariasis. The drug has also shown to be effective against hookworms (Ancylostoma duodenale and Necator americanus), but results of reported studies are inconsistent [1]. The mechanism of action of levamisole in helminthiasis is through its stimulation of autonomic ganglia (nicotinic receptors) of the worms. On exposure to the drug, immature and adult worms show spastic contraction followed by tonic paralysis. This mechanism seems to be common to other anthelminthics such as pyrantel and bephenium hydroxynaphthoate [2]. In higher doses, levamisole acts as an immunostimulant. It restores depressed cell-mediated immune mechanisms in peripheral T-lymphocytes, but may have marginal effects in immunologically competent individuals [3].
Uses:
Levamisole is used for initial and secondary immunodeficient conditions, autoimmune diseases, chronic and reoccurring infections, large intestine adenocarcinoma, helmintosis, and rheumatoid arthritis. Synonyms of this drug are decaris, tetramizole, and others.
Levimasole is also a drug of choice for ascardiasis. Numerous investigations show that a single dose of levamisole heals from 90 to 100% of patients with ascardiasis, in particular those infected with A. duodenale. It is less effective against ancylostomiasis and strongyloidiasis.
Pharmaceutical Applications:
The l-isomer of tetramisole, available as the monohydrochloride. The d-isomer has no anthelmintic activity. It is very soluble in water and is stable in the dry state.
Product picture:
Enterprise Certification:
Lihe Pharmaceutical Technology (Wuhan) Co., Ltd. is a pharmaceutical company integrating product development, production and chemical intermediates, specializing in the research, development, production and export of organic intermediates, pharmaceutical intermediates, chemical solvents and pesticides.Loacted in Hubei Province, involving pesticide, medicine, chemical industry, coating, dye, reagent, polyester, petrochemical and other fields. AOP provide excellent products and products for customers according to quality, quantity and time Service, established a good brand reputation and business reputation in the industry, won the trust and support of many customers at home and abroad.since its establishment, the company has always adhered to the principle of people-oriented, technology for survival, quality for credit, service tenet, consistent quality and reputation guarantee, continuous pioneering spirit of business is the cornerstone of our development, and the support and praise of..
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