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| Other Name: | Base & HCL;2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine Hydrochloride | EINECS:: | 230-902-1 |
|---|---|---|---|
| Density: | 1.0905 (rough Estimate) | Refractive Index: | 1.5700 (estimate) |
| Storage Temp.: | -20°C | Solubility: | Soluble In Methanol At 50mg/ml. Also Soluble In Dilute Acid Solutions. |
| Categories: | Bulk Drug Intermediates | Pka: | 7.67±0.20(Predicted) |
Factory Supply CAS No. 23076-35-9 Hydrochloride Best Price/High Quality
Porduct Description:
| CAS No: | 7361-61-7 |
| Molecular formula: | C12H16N2S |
| EINECS No.: |
230-902-1 |
| Melting point: | 140°C |
| Boiling point: | 334.2±52.0 °C(Predicted) |
| Type: | Pharmaceutical intermediates |
| Appearance: | Powder |
| Color: | White |
| Purity: | 99.9% |
| pka: | 7.67±0.20(Predicted) |
| Storage: | -20°C |
| Sample: | Available |
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Safety Profile:
Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.
Manufacturing Process:
2,6-Dimethylphenyl isothiocyanate, 31.0 g (0.2 mole), prepared from 2,6- dimethylaniline with thiophosgene, were added dropwise during 15 min to a well-stirred suspension of 15.0 g (0.2 mole) of 3-aminopropanol-1 in 100 ml of ether. The ether started to boil. Stirring under reflux was continued for 30 min, and the ether was then distilled off. The residue was treated with 100 ml of concentrated hydrochloric acid and boiled under reflux for 30 min. After cooling, it was diluted with water, filtered free from impurities, and the base was precipitated by the addition of concentrated sodium hydroxide solution. When recrystallized from benzene-ligroin, the resulting compound 2-(2,6- dimethyl-phenylamino)-4H-5,6-dihydro-1,3-thiazine, melting point 140-142°C (yield 90% of the theoretical).
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