94-09-7 Benzocaine Local Anesthesia Drugs

94-09-7 Benzocaine Local Anesthesia Drugs

Product Details

Product name	Benzocaine
CAS NO	94-09-7
Appearance	White powder
Purity	≥99%
Items of analysis	Specification
Identification	Consistent with the standard chart
Reactive identification	Orange red
Melting point	88ºC-92ºC
Less on drying	≤0.5%
Easy carbide	Comply with USP standards
Residue on ignition	≤0.1%
Heavy metals	≤10 ppm
Total impurity	≤1.0%
Assay	98-102%

Description:Benzocaine (ethyl p-aminobenzoate) is used topically by itself or in combination with menthol or phenol in nonprescription dosage forms such as gels, creams, ointments, lotions, aerosols, and lozenges to relieve pain or irritation caused by such conditions as sunburn, insect bites, toothache, teething, cold sores or canker sores in or around the mouth, and fever blisters. Benzocaine is a lipophilic local anesthetic agent with a short duration of action.Like most amino ester-type local anesthetics, it is easily hydrolyzed by plasma cholinesterase. Because of its low pKa, however, it is un-ionized under most physiological conditions and, therefore, can only bind to the lipid side of the local anesthetic receptor. It also can easily cross membranes into systemic circulation to cause systemic toxicities. Furthermore, being a PABA derivative, it has similar allergenic properties to procaine and is contraindicated with sulfonamide antibacterial agents.

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