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| Product Name: | Levamisole | CAS:: | 14769-73-4 |
|---|---|---|---|
| MF:: | C11H12N2S | MW:: | 204.29 |
| Mol File:: | 14769-73-4.mol | ||
| High Light: | Cas 14769-73-4 Levamisole,GMP Levamisole |
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Product Description
| Levamisole Basic information |
| Pharmacology and mechanism of action Indications Side effects Contraindications and precautions Interactions Preparations References |
| Product Name: | Levamisole |
| Synonyms: | L-6-PHENYL-2,3,5,6-TETRAHYDROIMIDAZOL(2,1-B) THIAZOLE;IMMUNOPURE(R) PHOSPHATASE SUPPRESSOR;LEVAMISOLE;LEVAMISOLE BASE;(s)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole;lepuron;levomysol;l-tetramisole |
| CAS: | 14769-73-4 |
| MF: | C11H12N2S |
| MW: | 204.29 |
| EINECS: | 238-836-5 |
| Product Categories: | |
| Mol File: | 14769-73-4.mol |
Description
Levamisole is the L-isomer of tetramisole and is more active than the racemic mixture. It was introduced in 1966 as a veterinary drug and a little later as a human anthelminthic drug against ascariasis. The drug has also shown to be effective against hookworms (Ancylostoma duodenale and Necator americanus), but results of reported studies are inconsistent [1]. The mechanism of action of levamisole in helminthiasis is through its stimulation of autonomic ganglia (nicotinic receptors) of the worms. On exposure to the drug, immature and adult worms show spastic contraction followed by tonic paralysis. This mechanism seems to be common to other anthelminthics such as pyrantel and bephenium hydroxynaphthoate [2]. In higher doses, levamisole acts as an immunostimulant. It restores depressed cell-mediated immune mechanisms in peripheral T-lymphocytes, but may have marginal effects in immunologically competent individuals [3]. The clinical implication of this effect in the treatment of helminthiasis is unknown.
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